For this question, answer in AT MOST two sentences (no semi colons allowed). Bec

Question

For this question, answer in AT MOST two sentences (no semi colons allowed). Because sox9 is an essential gene, you make a conditional sox9 strain that knockout sox9 in somatic gonad in the presence of a drug. You mate this sox9 strain to a sox9 knockout strain (so the mouse is a sox8: sox9 double mutant). You then perform the following experiments: You give the drug to a pregnant female mouse, so that .unit is knocked out in the somatic gonad of the embyros. What happens to the XY progeny? You give the drug to a 6 week male mouse. What happens to the mouse?

Explanation / Answer

You give the drug to a pregnant female mouse, so that sox9 is knocked out in the somatic gonad of the embryos. What happens to the XY PROGENY?

The XY progeny will undergo sex reversal from male to female.

Explanation: In the early gonad, the Sox9 autosomal gene need to be expressed to have the sertoli cell differentiation, and its expression in case of early XX gonad will result in female to male sex reversal at the same time when there is loss of function mutation in Sox9 in case of XY animals, then it bring the male to female sex reversal.

You give the drug to a 6 week male mouse. What happens to the mouse?

The male mice will lose the sertoli cells in the testes and they will die and it is replaced by empty space.

Explanation

Both Sox8 and Sox9 gene are needed for the maintenance of sertoli cells in the testes, when we inactivate or remove these two genes the sertoli cells present in the testes will lose their key characteristics, will not produce sperms and die.

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