In RNA induced gene silencing, how do the silencing processes begin and what maj
ID: 178258 • Letter: I
Question
In RNA induced gene silencing, how do the silencing processes begin and what major components participate? Select all answers that apply.
Short, double-stranded RNA molecules are recognized by either the RISC or RITS complex and the sense strand is degraded.
The RISC complex, guided by single-stranded RNA, can silence gene expression by affecting either mRNA stability or translation.
siRNA molecules are derived from single-stranded RNAs that are transcribed from the cell's own genome.
The RITS complex, guided by single-stranded RNA, recruits chromatin remodeling proteins that can repress transcription.
The Dicer complex can cleave both siRNA and miRNA precursors into siRNAs and miRNAs.
a.Short, double-stranded RNA molecules are recognized by either the RISC or RITS complex and the sense strand is degraded.
b.The RISC complex, guided by single-stranded RNA, can silence gene expression by affecting either mRNA stability or translation.
c.siRNA molecules are derived from single-stranded RNAs that are transcribed from the cell's own genome.
d.The RITS complex, guided by single-stranded RNA, recruits chromatin remodeling proteins that can repress transcription.
e.The Dicer complex can cleave both siRNA and miRNA precursors into siRNAs and miRNAs.
Explanation / Answer
Short, double-stranded RNA molecules are recognized by either the RISC or RITS complex and the sense strand is degraded.
a.Short, double-stranded RNA molecules are recognized by either the RISC or RITS complex and the sense strand is degraded.
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