In RNA induced gene silencing, how do the silencing processes begin and what maj

Question

In RNA induced gene silencing, how do the silencing processes begin and what major components participate? Select all answers that short, double-stranded RNA molecules are recognized by either the RISC or RITS complex and the sense strand is degraded. The RISC complex, guided by single-stranded RNA, can silence gene expression by affecting either mRNA stability or translation. siRNA molecules are derived from single-stranded RNAs that are transcribed from the cell's own genome. The RTS complex, guided by single-stranded RNA, recruits chromatin remodeling proteins that can repress transcription. The Dicer complex can cleave both siRNA and miRNA precursors into siRNAs and miRNAs.

Explanation / Answer

Answer is .E . The Dicer complex can cleave both siRNA and miRNA precursors into siRNAs and miRNAs.

Reason:

The RNA-induced silencing complex, or RISC, is a multiprotein complex, specifically a ribonucleoprotein, which incorporates one strand of a single-stranded RNA (ssRNA) fragment, such as microRNA (miRNA), or double-stranded small interfering RNA (siRNA).[1] The single strand acts as a template for RISC to recognize complementary messenger RNA (mRNA) transcript. Once found, one of the proteins in RISC, called Argonaute, activates and cleaves the mRNA. This process is called RNA interference (RNAi) and it is found in many eukaryotes; it is a key process in gene silencing and defense against viral infections.

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