Protein synthesis of a soluble ER-resident protein is ini4ated on __________ rib

Question

Protein synthesis of a soluble ER-resident protein is ini4ated on __________ ribosomes, and terminated on ___________ ribosomes.

A. Free (Cytosolic)

B. ER-associated

Protein synthesis of ribosomal proteins, soluble cytoplasmic proteins, is ini4ated on __________ ribosomes, and terminated on ___________ ribosomes.

A. Free (Cytosolic)

B. ER-associated

Why are rough ER-targe4ng signal sequences not seen on

secreted proteins?

A. The signal sequence is cleaved off by signalase

B. There are only smooth ER signal sequences

C. A protease at the plasma membrane cleaves the signal just before secre4on

D. Secreted proteins don’t need a signal sequence

Which compartment of the cell is most like the outside of

the cell?
A. Cytosol B. ER lumen C. Lysosome D. Nucleus

Explanation / Answer

3. Secreted proteins don’t need a signal sequence because they can easily diffuse through the plama membrane.

4. A. cytosol is rich in fluids like extracellular environment.

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