I found the following description on the CDC website about the new Ebola Viral D

Question

I found the following description on the CDC website about the new Ebola Viral Diseases Vaccine that is in trial: “The vaccine being used in STRIVE is rVSV-ZEBOV, or Vesicular Stomatitis Virus Zaire ebolavirus vaccine. To make this vaccine, the vesicular stomatitis virus is weakened by removing one of its genes. That gene is replaced with a single Ebola virus gene.” The vesicular stomatitis virus infects insects, cattle, horses, and pigs. This virus can lead to flu like symptoms in humans

• Please describe what type of vaccine this is, whether this would illicit a natural or an artificial and a passive or an active immune response, and how likely the individual receiving this vaccine is to develop Ebola symptoms. Please justify your answers.

Explanation / Answer

This vaccine is a type of recombinant, replication-competent vaccine. It would illicit an active acquired immunity like most vaccines. These vaccines contain a live microbe that is weakened ito such an extent that it is no longer capable of causing disease. However, they could get mutated and regain the ability to cause the disease. This risk is negligibe with people having a healthy immune system but there is greater risks in people whose immune systems have already been compromised.

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