for this molecular diagram that shows the role of Tp53 gene in ovarian cancer Cr

Question

for this molecular diagram that shows the role of Tp53 gene in ovarian cancer

Create a linear molecular diagram of the illustrated pathway " role of Tp53" in cancer" simplify please , thanks!!

Primary events: initiation, adaptation and copy number change Secondary events: molecular subtype diversification Tertiary events mutations to facilitate tumour evolution p53 loss HRR deficiency BRCA loss Platinum sensitivity Chromosomal instability Widespread CN change Global Molecular subtype-specific changes In gene copy number event expression C1 C2 C4 C5 Individual tumour variation Nature Reviews Cancer

Explanation / Answer

Mutation ( failure of tumor suppressor genes) ---->

P53 loss

------->

BRCA loos

-------->

chrosomal instabilityàchanges in gene expression

------>

failure of apoptosis

----->

tumor

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