In the following sequence of mRNA: 5\'-A-U-C-A-C-G-G-C-U*-A-A-C-C-G-A-U-C-G-A-3\

Question

In the following sequence of mRNA: 5'-A-U-C-A-C-G-G-C-U*-A-A-C-C-G-A-U-C-G-A-3' What would happen to the protein that would be made if a mutation in DNA changed the U* to an A? a. A disulfide bridge could be lost. b. The stop codon would be lost and the wrong protein would be made. c. A similar hydrophobic amino acid would be added to the protein. d. Nothing, the same amino acid would be added. e. A stop codon would be generated and protein synthesis would stop. DNA exists as a helix of two DNA molecules twisted around each other. What type of bond holds DNA in this double helix configuration? a. hydrogen bonds between bases

Explanation / Answer

Ans. 5’- AUC     ACG      GCU      AAC      CGA      UCG   A -3’        - normal mRNA

                Ile-    The-     Ala-      Asn-      Arg-     Ser                     - Normal protein    

AUC      ACG      GCA      AAC      CGA      UCG   A -3’        - mutated mRNA

                Ile-    The-     Ala-      Asn-      Arg-     Ser                     - Normal protein    

Both the codons “GCU” and “GCA” encode the same amino acid. Thus, the resultant protein translated from mutated mRNA remains identical to the normal protein.

So, correct option: d. Nothing, the same amino acid would be added.

All other options are incorrect because they indicate the situation not possible for this mutation that yields identical protein.

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