Order the following steps in the pyruvate dehydrogenase reaction. The answer is

Question

Order the following steps in the pyruvate dehydrogenase reaction. The answer is scored as ALL OR NOTHING, so all steps must be in the correct order for credit.

Question 5 options:

a) Pyruvate and thiamine pyrophosphate react form hydroxyethyl-TPP. CO2 is released.

b) The reduced coenzyme bound to PDH is reoxidized using electrons from FAD.

c) An acetyl group is added to a coenzyme bound to PDH, forming acetyl-dihydrolipoamide.

d) The acetyl group is transferred to CoA, forming acetyl-CoA.

e) Electrons from FADH2 are transferred to NAD+ forming NADH and H+.

Explanation / Answer

Answer:

Order the following steps in the pyruvate dehydrogenase reaction.

The correct order is:

a) Pyruvate and thiamine pyrophosphate react to form hydroxyethyl-TPP. CO2 is released.

b) An acetyl group is added to a coenzyme bound to PDH, forming acetyl-dihydrolipoamide.

c) The acetyl group is transferred to CoA, forming acetyl-CoA.

d) The reduced coenzyme bound to PDH is reoxidized using electrons from FAD.

e) Electrons from FADH2 are transferred to NAD+ forming NADH and H+.

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