Order the following statements to illustrate the correct cascade of events that

Question

Order the following statements to illustrate the correct cascade of events that occurs after ligand binding of G protein coupled receptor (heptahelical receptor) 1. Degradation of cAMP by phosphodiesterase 2. Dissociation of Gb and Gy subunits 3. G protein exchanges GTP for GDP in the G alpha subunit 4. Activation of adenyly Cyclades to generate cAMP Order the following statements to illustrate the correct cascade of events that occurs after ligand binding of G protein coupled receptor (heptahelical receptor) 1. Degradation of cAMP by phosphodiesterase 2. Dissociation of Gb and Gy subunits 3. G protein exchanges GTP for GDP in the G alpha subunit 4. Activation of adenyly Cyclades to generate cAMP 1. Degradation of cAMP by phosphodiesterase 2. Dissociation of Gb and Gy subunits 3. G protein exchanges GTP for GDP in the G alpha subunit 4. Activation of adenyly Cyclades to generate cAMP

Explanation / Answer

It all starts when the G protein exchanges GDP for GTP. then:

2.Dissociation of Gb and Gy subunits (For "release" of the protein)

4. Activation of adenyly Cyclases to generate cAMP (it´s the main objective)

1. Degradation of cAMP by phosphodiesterase (this is how the protein starts the "autocontrol" method)

3. G protein exchanges GTP for GDP in the G alpha subunit (This "turn off" your protein)

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