The standard free energy change of phosphate hydrolysis is shown below for sever

Question

The standard free energy change of phosphate hydrolysis is shown below for several molecules in the glycolytic pathway.

1. (A) Phosphorylation of glucose to produce glucose-6-phosphate has G' = _____  kJ/mol without the use of ATP.

(B) Coupling phosphorylation with ATP hydrolysis gives G' = ______ kJ/mol.

2. Using concentrations of intermediates found in a cell, the phosphorylation of glucose using inorganic phosphate has G' = 19.7 kJ/mol, while phosphoryl transfer from ATP (ATP investment) results in G' = -34.5 kJ/mol. What does this tell you about the values of Q and Keq for the phosphorylation of glucose with and without energy investment from ATP?
A.   Without ATP investment, Q > Keq, and with ATP investment Q > Keq.

B.   Without ATP investment, Q > Keq, and with ATP investment Q = Keq.

C.   Without ATP investment, Q > Keq, and with ATP investment Q < Keq.

D.   Without ATP investment, Q < Keq, and with ATP investment Q > Keq.

Molecule G' (kJ/mol) Phosphoenolpyruvate 61.9 1,3-Bisphosphoglycerate 49.4 ATP ADP + Pi 30.5 Fructose-6-phosphate 15.9 Glucose-6-phosphate 13.8

Explanation / Answer

1) A) Phosphorylation of glucose to produce glucose-6phosphate hascome?G°'=9.4kj/mol without the use of ATP.

2) b) without ATP investment Q>keq, and with ATP investment Q= Keq

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