Match the following closely related bacterial strains with their correct descrip

Question

Match the following closely related bacterial strains with their correct description: Shigella a. An acid tolerant bacteria that carries a type 3 secretion system on a plasmid. Uses the secretion system to escape the phagosome and propels itself around the host cell using actin filaments. E. coli strain HS A bacteria that carries a type 3 secretion system on a pathogenicity island. Uses the secretion system to tightly adhere to the intestinal epithelium and form actin pedestals. E. coli 0157:H7 C. A harmless commensal of humans isolated from a volunteer. Has no type 3 secretion system or other virulence factors. d. A bacterial species that usually carries two type 3 secretion systems on different pathogenicity islands. Uses the secretion system to stay safely inside a

Explanation / Answer

E.coli strain HS:

E.coli strain HS (pFamp) R is a strain bacteria that contains the F-amp plasmid that codes for resistance to ampicillin and streptomycin. This specific strain serves a useful function in the body by suppressing the growth of harmful bacterial species. E.coli HS was originally obtained from a laboratory scientist at Walter Reed Army Institute of Research. This specie can colonize the human gastrointestinal tract with NO signs of disease.

Salmonella:

Salmonella is a facultative intracellular pathogen, which invades host epithelial cells and macrophages. The pathogen uptake into host cells is mediated through virulence factors, which are injected into phagocytic and non-phagocytic host cells via TWO type 3 secretion systems.

Shigella:

Shigella is a gram-negative bacterium known to be the causative agent of bacillary dysentery. This strain is often more resistant to gastric acid than other intestinal bacteria such as Salmonella and E.coli. Shigella uptake into resident macrophages, escape from the phagosome and release from dead macrophage into the submucosa. The bacterial effectors induce actins tails.

E. coli O157:H7:

This contains a chromosomal pathogenicity island, a locus of enterocyte effacement, encoding the type 3 secretion apparatus and bacterial effectors that lead to intimate adhesion to host intestinal epithelial cells.

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