Assume that a drug is developed that prevents the prometaphase stage of mitosis

Question

Assume that a drug is developed that prevents the prometaphase stage of mitosis from occurring but does not prevent any stages of mitosis prior to prometaphase from occurring nor does it interfere with any part of interphase. What will be the immediate consequence of this drug?

1-DNA replication will not happen so that each chromosome will contain a single DNA molecule. 2- The chromosomes will not be able to condense. 3- Sister chromatids will not be present. 4-Spindle microtubules will not be able to attach to chromatids. 5- Sister chromatids will separate and move toward opposite poles prematurely.

Explanation / Answer

The answer is 5- Sister chromatids will separate and move toward opposite poles prematurely.

Explaination:

In prometaphase, sister chromatids are captured by microtubules stemming from centrosomes on opposite ends of the cell. Once they have captured chromosomes, the kinetochore microtubules begin to exert force on the chromosomes moving them prematurely.

At the end of prometaphse, DNA replication occurs in S phase of prophase, chromosomes are condensed. Sister chromatids are created during S phase. Thus, the answer is that sister chromatids will separate and move toward opposite poles prematurely.

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