Recall from the practice problem set 2 that in people with Fabry\'s disease, the
ID: 184638 • Letter: R
Question
Recall from the practice problem set 2 that in people with Fabry's disease, the cornea of the eye shows a characteristic clouding because cells that form blood vessels that supply the cornea accumulate a glycolipid molecule called Gb3. This molecule builds up in membranes and vesicles in the cells of Fabry's patients. Use this information to answer some of the following questions. 0 OH OH OH O H OH OH OH H OH H H OH H OH This is Gb3. Carbons are at all corners unless otherwise noted. Hydrogens attached to carbons are not shown.Explanation / Answer
Ans-1) Gb3 is made up of lipids.
Ans-2) Proteins are the enzymes that synthesize and degrade Gb3.
Ans-3) Genes that code for the enzymes that degrade Gb3 are found in nucleus.
Ans-4) Genes that code for the enzymes that degrade Gb3 are made up of nucleic acid.
Ans-5) Ribosome is the specific protein/RNA complex that synthesizes polypeptides.
Ans-6) Smooth Endoplasmic Reticulum synthesizes the lipid portion of Gb3 molecules.
Ans-7) Polypeptides that are destined for secretion are synthesized at the membrane and in the lumen of Rough endoplasmic reticulum.
Ans-8) Enzymes that degrade Gb3 are active in Lysosomes.
Ans-9) Golgi apparatus adds a carbohydrate tag to the enzyme that degrade Gb3.
Ans-10) The surface of rough endoplasmic reticulum is rough due to the presence of ribosomes.
Ans-11) Chloroplast is not found in animals.
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