Aspirin is a weak acid that is taken up into the bloodstream by diffusion throug

Question

Aspirin is a weak acid that is taken up into the bloodstream by diffusion through cells lining the stomach and the small intestine. Aspirin crosses the plasma membrane of a cell most effectively in its uncharged form; in its charged form it cannot cross the hydrophobic lipid bilayer of the membrane. The pH of the stomach is about 1.5 and that of the lumen of the small intestine is about 6.0. Where is aspirin absorbed more efficiently, in the stomach or in the intestine? Explain your reasoning Aspirin is a weak acid that is taken up into the bloodstream by diffusion through cells lining the stomach and the small intestine. Aspirin crosses the plasma membrane of a cell most effectively in its uncharged form; in its charged form it cannot cross the hydrophobic lipid bilayer of the membrane. The pH of the stomach is about 1.5 and that of the lumen of the small intestine is about 6.0. Where is aspirin absorbed more efficiently, in the stomach or in the intestine? Explain your reasoning

Explanation / Answer

Most absorption per unit time occurs in the stomach.Note: as the aspirin spends more time in the intestine, substantial absorption willoccur in the intestine.

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