2. The enzyme PFK-1 catalyzes the 3d step in the glycolytic pathway (as shown be

Question

2. The enzyme PFK-1 catalyzes the 3d step in the glycolytic pathway (as shown below) and is known to be an allosteric protein with multiple regulatory sites. Shown below is a graph of PFK-1 activity (defined as a % of it's Vmax) vs. the [ATP]. Given this data and information describe why PFK-1 activity increases sharply at lower [ATP] and then experiences a steady decline in activity as [ATP] increases passed a threshold level. (5 points) fructose-6-phosphate + ATP fructose-1,6-bisphosphate + ADP G_-22.2 kJ/mol 100 80 4 20 0 ATP

Explanation / Answer

When Fructose 6 Phosphate combines with lower amounts of ATP it helps to convert into Fructose 1,6 Bisphosphate however when the quantity of Fructose 6 phosphate is less and ATP is more it tends to act as an inhibitor to the enzyme Phosphofructokinase thus at the highest levels of ATP there is lower percentage of Fructose 1,6 Bisphosphate being formed.

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