8. Protein activity can beregulated regulated by the addition of small molecules

Question

8. Protein activity can beregulated regulated by the addition of small molecules, uch as a phosphat by the addition of smiall molecules, Sc s a phspht group through a process called phosphorylation. The protein below is the same as from the n question 6. The Tyr108 has been phosphorylated. of re actron male He Tyr108 Arg7 HN H2N NH2 HN NH SH NH2 H2N Arg116 Glu78 Phe57 Cys75 A. Draw in the potential interactions that can occur between this phosphate group and the surrounding amino acids in the active site. B. Do you think the phosphorylation of this active site will increase or decrease protein activity? Explain.

Explanation / Answer

A. Hydrogen bonding occurs between oxygen in phosphate group and hydrogen in arginine (Arg).

B. Phosphorylation of this active site will increase the protein activity as the phosphate group forms hydrogen bond with the surrounding arginine. It increases the stability of the protein and thereby increasing protein activity.

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