The graph below depicts the effects of ethanol on receptor-mediated endocytosis

Question

The graph below depicts the effects of ethanol on receptor-mediated endocytosis of a glycoprotein in rat cells. Which of the following conclusions can be drawn based on the data provided? 1600 1400 1200 1000 800 600 E 400 200 -Chow -control Ethanol 0 30 60 90 105 120 135 150 2500 2000 1500 1000 500 -Chow Control Ethanol 0 30 60 90 105 120 135 150 Time (min) Select one: O a. Ethanol inhibits receptor-mediated endocytosis by blocking clathrin association with the transmembrane receptor o b. The effects of ethanol on receptor-mediated endocytosis increase with increasing ethanol concentration O c. Ethanol causes cell death and therefore reduced receptor-mediated endocytosis O d. Ethanol may or may not directly affect receptor-mediated endocytosis but could affect global cell function O e. The chow fed to the rats contains traces of ethanol that is provided to the rats as a positive contropss out cross out cross out cross out cross out

Explanation / Answer

Correct answer would be:

a.Ethanol inhibits receptor-mediated endocytosis by blocking clathrin association with transmembrane receptor.

Reason:Ethanol has been reported to impair the  process of clathrin mediated internalization of glycoprotein known as asialoglycoprotein by asialoglycoprotein receptor and this often leads to cell death or apoptosis in mice fed with ethanol.

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