1. Using these 10 amino acids as building blocks, propose a sequence for an inte
ID: 188563 • Letter: 1
Question
1. Using these 10 amino acids as building blocks, propose a sequence for an integral protein. Your sequence must have a transmembrane portion of a length of 6 amino acids, and you must have at least 2 amino acids inside and 2 outside the cell. Draw and label your polypeptide with respect to the plasma membrane (you can use abbreviations and you do not need to draw the molecular structures). Be sure to clearly label ALL elements of your drawing. H3 Glycine (G, Gly) Proline (P, Pro) coo H,N-COOM H2N COOH H3N-C-H HN-C-H H2N COOH alanine phenylalanine Cysteine OH Tyrosine serine glutamic acid Lysine HistianeExplanation / Answer
Transmembrane amino acids: glycine, alanine, tyrosine, phenylalanine, serine, glutamic acid
cytoplasmic domain : proline, cysteine
Justification : aliphatic and neutral amino acids are present in the transmembrane region, while
extracellular domain : lysine and histidine
Justification : basic amino acids play a role in signaling
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