Comparing MHC I a-chain and b2-microglobulin (b2-MG) in a family of six, includi

Question

Comparing MHC I a-chain and b2-microglobulin (b2-MG) in a family of six, including mom, dad and two daughters and two sons, 1) which chain is identical among all six people and why? And 2) which chain is involved in binding to TCR/peptide?

3) Among the six family members, which pair is more likely to find similarity between the two for possible transplant, father/mother, mother/daughter, father/son, father/daughter, or siblingsr? Why?

4) Deficiency in b2-MG was reported in 2 siblings. How does the b2-MG deficiency affect their immune system?

5) Hypothetical question: if an individual had genetic alterations in MHC-I, resulting in deletion of HLA-B, C, E, F and G gene loci, leaving only HLA-A intact, what would you expect of the immune system in this individual and why? Would this individual have similar phenotype to the one seen with the deficiency in b2-MG?

Explanation / Answer

Answer 1: The MHC1 3 and the b2-microglobulin (b2-MG) are the highly conseved regions in MHC 1 molecule and hence these chains are identical amongst all six people. Since the 1/2 heterodimer is involve in the peptide binding, it is variable in nature and would be different in the family members.

Answer 2: The central region of the 1/2 heterodimer is involved in binding to TCR/peptide

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