Researchers collected DNA from a large population of individuals. They analyzed

Question

Researchers collected DNA from a large population of individuals. They analyzed the sequence of the SED gene, which contains 9 exons and 8 introns, and is thought to be the gene involved in SED disease. In some individuals, they identified the following mutations (compared to the wild type SED gene) mutation 1 a change of a codon in the middle of exon 1 from UAU to UAG mutation 2. a change of a codon in the middle of exon 7 from UGG to UGU mutation 3. a change of a sequence in the middle of intron 3 from UAU to UGU mutation 4. a change of a codon in the middle of exon 3 from UAU to UAC Below is an abbreviated codon table: UAU-Tyr UAC-Tyr UAA-Stop UAG -Stop UGU - Cys UGC Cys UGA- Stop UGG Trp Would mutation 1 likely lead to the production of a protein that has a different amino acid sequence than the wild type SED protein? O No Submit Request Answer

Explanation / Answer

ANSWER - NO

In mutation 1 change of codon from UAU to UAG. This is an example of non sense codon. A point mutation in a sequence of DNA that results in a premature stop codon and arrest of protein synthesis. This leads to incomplete, and usually nonfunctional protein product.

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