26 - Suppose a defective nucleotide is present in a DNA biosynthesis reaction th

Question

26 - Suppose a defective nucleotide is present in a DNA biosynthesis reaction that has no hydroxyl group on the 3' carbon of the deoxyribose sugar. What effect would that have on DNA replication?

A- This nucleotide cannot be added to the growing strand, so replication will stop right away.

B- The direction of replication will be reversed (from 3' to 5') after this nucleotide is added.

C- This nucleotide will be added to the growing strand, and then DNA synthesis will stop.

D- No effect. DNA replication will continue normally, and two DNA molecules will be generated.

Explanation / Answer

26.

Answer: C- This nucleotide will be added to the growing strand, and then DNA synthesis will stop.

Because, the hydroxyl group helps in the formation of ester bond during elongation of DNA strand. Two nucleotides are linked through3'-5' phosphodiester linkage.

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