6. Previous studies of breast cancer have found that inherited mutations, BRCA1/

Question

6. Previous studies of breast cancer have found that inherited mutations, BRCA1/2, are associated with an increased risk of breast cancer in women. The cumulative incidence of breast cancer among women with the BRCA1/2 is estimated to be 800/100,000 over 30 years; the incidence among women without the mutation is 80/100,000. What is the attributable risk of BRCA1/2 for breast cancer based on these data? What is the attributable risk proportion? a. b. What is the meaning of the attributable risk in the exposed? c. Suppose now that the prevalence of BRCA 1/2 in the target population is 1%. Calculate the population attributable risk. Show your reasoning and the calculations for full credit. Interpret the meaning of the population attributable risk. d.

Explanation / Answer

Ans b. Attributable risk is the difference in the rate of condition between an exposed condition and an unexposed condition. It is the difference in the cumulative indices between the risk differences or rate differences.   

Ans d. Population attributable risk is the proportion of the incidence of a disease in the population that is due to exposure. It is the incidence of a disease in the population that would be eliminated if exposure was eliminated.

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