6-9 6. When in mitosis does the cell reach the M checkpoint, and what is its fun

Question

6-9 6. When in mitosis does the cell reach the M checkpoint, and what is its function? Be sure to include mention of the protein cohesin and the enzyme separase. 7. Imagine a cell with a genetic mutation that prevents it from synthesizing functional cohesins. At what stage might the cell cycle be disrupted? 8. Cytokinesis, the last stage of the mitotic M-phase, divides the original cell into two daughter cells. How do these daughter cells compare genetically? 9. How does the size of the 2 daughter cells immediately after cytokinesis compare to the size of the parent cell at the end of G2? Draw the size of a parent cell and then draw its 2 daughter cells for size comparison. (hint: What happens to the size of the daughter cells during interphase???)

Explanation / Answer

A mitotic cell cell reaches M check point during metaphase when all chromosomes are arranged on mitotic spindle at equator.

It triggers a mechanism to ensure entry into Anapase stage so that sister chromatic separate.

This checkpoint leads to activation of protein separate that causes disruption/cutting of protein cohesins that are responsible for attachment of sister chromatids.Cutting of this protein cohesin causes sister chromatid separation. This separation takes place during anaphase.

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