d Describe which allosteric model Model A at right is most consistent with BLLDH

Question

d Describe which allosteric model Model A at right is most consistent with BLLDH regulation. S substrate- bound enzyme. Explain your logic and list one example of BLLDH regulation given above in support of your conclusion. 6 pts) Model B You can look at substrate binding in the absence of NADH to uncouple binding from catalysis Let's say that the Ko of NADH-free BLLDH for pyruvate is 1 M in the R state. Given that the Hill Coefficient is 2, what fraction of 1 nM BLLDH is bound to substrate at 5 uM pyruvate? [4 pts]. d)

Explanation / Answer

C) Model b.

According to the concerted model, the conformation all subunits change simultaneously. All subunits change conformation from inactive T conformation to active R conformation at the same time. The binding of first molecule of substrate to one subunit facilitates the binding of the second substrate molecule to ither subunit i., cooperative binding.

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