Consider a SIM controlled by regulator X which activates downstream genes Zi, i=

Question

Consider a SIM controlled by regulator X which activates downstream genes Zi, i= 1 .. n genes with thresholds Ki. At time t=0, X begins to be produced at a constant rate . (a) Are there biological reasons that favor placing the thresholds Ki much smaller than the maximal level of X? Consider the case in which X is an activator that begins to be produced at time t=0, and consider the effects of cell-cell variations in the production rate of X. (b) Would a design in which X is a repressor whose production stops at time t=0 provide more robust temporal programs? Explain.

Explanation / Answer

a)The reason behind keeping lower Ki value that is smaller than X is to have more production and higher advantage, as in cells where X is lower than Ki has lead to non-production of Zi genes and cellular cycle is affected. As above mentioned X depends on (X is directly proportional to ) and for different cell to cell types varies and this tells us that few cell types may have higher than other cell types. Keeping lower threshold also provides advantage of ensurity that all genes are expressed well.

b) When X production doesn't occur both and Ki will be affected as a result production of Zi genes are affected and it is less produced leading to activation time of X as robust with change in production rate. such robustness can be helpful in providing more regulated temporal programs in the network of cellular process.

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