The figure below shows GDP in the binding pocket of a G protein NH +Oo NH Lys OH

Question

The figure below shows GDP in the binding pocket of a G protein NH +Oo NH Lys OH OH yr Glu Arg a) Circle the strongest interaction that exists between: i) the side chain of Lys and the phosphate group of GDP van der Waals ii) the side chain of Glu and the nibose group of GDP van der Waals ii) the side chain of Tyr and the guanine base of GDP van der Waals covalent hydrogen bond ionic covalent hydrogen bond ionic covalent hydrogen bond ionic and examine their Comaider the sze and the naueepolail ydhretcts on of the G be bndin b) You make mutations in the GDP the binding of GDP. Consider the size and the nature (e.g hydrophobicity) of the amino acid side chains and and give the most likely reason why each mutation has the stated effect. Consider each mutation independently. on i) Arg is mutated to a Lys, resulting in a G protein that still binds GDP. i) Asp is mutated to a Tyr, resulting in a G protein that cannot bind GDP.

Explanation / Answer

lAns- a-1 ans-ionic bond - because it a electrostatic forces that binds oppositely charged ions together.

2 ans-hydrogen bond- is a chemical bond between the hydrogen atom and an electronegative atom.

3 ans- hydrogen bond

Ans-b ans-arginine and lysine both are positively charged resulting ionic strength of phosphate group will be same.

2 ans-tyr is larger than Asp and tyrosine is making hydrogen bond with the ribose sugar, and GTP will not bind.

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