An elderly woman presents with spiking fever, shaking chills, nausea, and costov

Question

An elderly woman presents with spiking fever, shaking chills, nausea, and costovertebral angle tenderness. Urine cultures are positive and she is hospitalized for pyelonephritis. Her glomerular filtration rate (GFR) decreases with a resultant increase in the concentration of NaCl delivered in the intraluminal fluid to the thick ascending limb of the loop of Henle.

Under these conditions, the macula densa will increase the formation and release of which of the following substances?

Explanation / Answer

When Nacl concentration is high, macula densa will increase the production of Adinosine. Whereas when Nacl concentration is low, macula densa will trigger juxtaglomerular apparatus to increase the production of renin.

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