How, specifically, might the following mutations destabilize the folding of a pr

Question

How, specifically, might the following mutations destabilize the folding of a protein? (What enthalpic and/or entropic factors would be affected?) a. a mutation that replaces a leucine residue in the hydrophobic core with alanine b. a mutation that replaces a leucine residue in the hydrophobic core with lysine c. a mutation that replaces an alanine residue in the middle of an alpha helix with proline

mutation that replaces a leucine residue in the hydrophobic core with alanin

a mutation that replaces a leucine residue in the hydrophobic core with lysin

a mutation that replaces an alanine residue in the middle of an alpha helix with proline

Explanation / Answer

Entropy and enthalpy of alanine is less than leucine. So, both will be decreased.

Entropy and enthalpy of lysine is more than leucine so both increases.

Enthalpy and entropy of proline is less. So, both will be decreased.

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