ALS has been associated with the following genetically encoded changes at variou

Question

ALS has been associated with the following genetically encoded changes at various positions in the angiogenin protein. For each substitution, answer the associated T/F question(s). 4. AsnLeu This substitution decreases polarity This substitution results in a change in size Pro Ser This change would increase the range of allowable angles for this residue IleVal The new residue has lost the -branching of the original The new residue is smaller than the original Pro Leu This would change the likelihood of this residue being buried in the core of the tertiary structure Lys- Glu This change would make the protein less water-soluble This substitution conserves hydrogen bond donor capability (assume pH 7) His Arg This change conserves the capability of forming an ionic bond with Glu

Explanation / Answer

1. True

2. False

3. True bcoze proline inhibits all these things.

4. False

5. True valine have structure which is smaller than isoleucine.

6. True.

Proline is an amino acid which have imino group and burried inside and leu is hydrophilic amino.acid so can leaves on the surface.

7. True

lysine is an basic amino acid and glutamate is acidic amino acid that is why it affects the solubility.

8. True.

Same due to the change or basic amino acid with acidic amino acid which have COOH group.

9. False both are basic amino acids and can form Bond as required.

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