Why are the mutations K65R and D113E, both causing drug resistance such a surpri

Question

Why are the mutations K65R and D113E, both causing drug resistance such a surprise, whereas, the mutations Q151M and Q151N are not such a surprise. Explain the reasoning behind this. The answer to this question is not found in the paper, but based on what you now understand about mutations in general Why are the mutations K65R and D113E, both causing drug resistance such a surprise, whereas, the mutations Q151M and Q151N are not such a surprise. Explain the reasoning behind this. The answer to this question is not found in the paper, but based on what you now understand about mutations in general

Explanation / Answer

K = Lysine
R = Arginine
Both these amino acids are synonymous.
D = Aspartic acid
E = Glutamic acid.
Both these amino acids are also synonymous.
It is interesting to note that synonymous mutations showed a different phenotype compared to non-synonymous mutations. Q and M or Q and N are completely different amino acids.

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