Write an in depth question (don\'t answer it) about the following subject: Prolo

Question

Write an in depth question (don't answer it) about the following subject: Prolonged treatment with iodine, as a wound disinfectant, is detrimental to the structure of collagen underlying the wound site. Diabetic patients are more prone to injuries to limb extremities. Wounded extremities are commonly amputated to prevent the spread of infection to the rest of the body followed by low dose iodine application to the wound site. We present result to demonstrate specific disintegration of collagen fibrils in rat tail tendons, from a short iodine treatment. A logical extension to the studies on tendons would be to understand the how they interact with muscles and the stress-strain relation of this system that, results in transfer of load (motion). The muscle-tendon junction (MTJ) is one of the most complicated collagenous tissues, from a material and properties perspective. A study of changes in the molecular and macroscopic strain with the application of stretch can be of great value in improving surgical methods on tissues presenting or possessing a muscle-tendon transition, for example heart valves, sphincters etc. Preliminary data on the “molecular” (using XRD) and macroscopic (using microscopy) stress-strain relations will be shown.

Explanation / Answer

Question: if the effect of iodine on collagen fibers can be detrimental when used in high concentration, what might be the effects of various stressors on collagen that underlies the skin.

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