1) The figure below is from Reitveld et al.\'s (2013) study entitled \"GWAS of 1
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1) The figure below is from Reitveld et al.'s (2013) study entitled "GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment". What is the probability that alleles at locus rs9320913 are associated with educational attainment purely by chance (either as a raw decimal or a percent) [note: y-axis -LoD]? (2 pts) rs9320913 100 rs9320913 10 0.8 0.6 04 02 80 60 20 KLHL32 MIR21 13 C6orf168 C6orf167 98.5 Position on chr6 (Mb) 97.5 98 9.5 2) Reitveld et al. (2013) [which, by the way, had 203 authors!!!], found that the combined effects of the three loci with highest LoD scores (of which rs9320913 is one) explained ~2% of the variance in educational attainment and cognitive function. If the LoD score is so strong, explain why these genes, although strongly associated with the traits of interest, have so little impact on phenotype. (2 pts) 3) "[James Watson] told the Sunday Times in 2007 that while people may like to think that all races are born with equal intelligence, those "who have to deal with black employees find this not true"." (Yes, like Watson and Crick. This quote is from an Opinion piece in The Guardian in 2014. Also, I am compelled to point out that there are also no "races" in Homa sapiens, only ethnicities). In the quote, Watson is positing that some ethnicities are genetically-predetermined to be less intelligent than others. What does the work of Reitveld et al. (2013) tell us about the likelihood of a genetic basis for intellect with ethnicity-specific alleles? (1pts)Explanation / Answer
A} rs 9320913 explains 0.022% of phenotypic variance in replication sample.
B} the genetic architecrure of complex behavioural traits are far more diffuse than complex behavioural trait. And here the sample used is very less so the outcome resukt is not so broad.
C} cognitive power and intelligence can be linked up with gene but they are not immune to environment so as environment factors taken in acct. the gene shows variation . With ethnicity specific allels genetic basis is there but does not account phenotypically as the study was not carried out with large samples .
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