Consider the following hydropathy plot for a multipass transmembrane protein in

Question

Consider the following hydropathy plot for a multipass transmembrane protein in the ER membrane. The asterisk indicates the position of some positively-charged amino acids. Which of the following is likely to be true? +25 0 Question Completion Status: -25 100 200 Residue number A. Both the C-terminus and the N-terminus are in the cytosol B. Both the C-terminus and the N-terminus are in the ER lumen ° C. The C-terminus will be in the ER-lumen and the N-terminus is in the cytosol D. none of the above

Explanation / Answer

We can say that both C and N terminal of the protein is in the ER lumen. Because in protein the terminal amino acids have approx -0.5 negative charge in the proteins structure that is why they exist in the lumen of ER.

hydropathy index of any protein is determined by the charge present on the amino acids.

When the amino acids of C and N terminal are positivel charged then they exist in the cytoplasm.

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