Consider the following hydropathy plot for a multipass transmembrane protein in

Question

Consider the following hydropathy plot for a multipass transmembrane protein in the ER membrane. The asterisk indicates the position of some positively-charged amino acids. Which of the following is likely to be true?

Both the C-terminus and the N-terminus are in the cytosol

Both the C-terminus and the N-terminus are in the ER lumen

The C-terminus will be in the ER-lumen and the N-terminus is in the cytosol

none of the above

Both the C-terminus and the N-terminus are in the cytosol

Both the C-terminus and the N-terminus are in the ER lumen

The C-terminus will be in the ER-lumen and the N-terminus is in the cytosol

none of the above

Explanation / Answer

Option C: The C-terminus will be in the ER-lumen and the N-terminus is in the cytosol

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