Glucose-6-phosphate dehydrogenase is also found in yeast, The KM for glucose-6-p
ID: 197682 • Letter: G
Question
Glucose-6-phosphate dehydrogenase is also found in yeast,
The KM for glucose-6-phosphate in yeast is 2x10^-5 The KM for NADP1
is 2 1 x10^-6 Yeast glucose-6-phosphate dehydrogenase can be
inhibited by a number of cellular agents whose KI values are listed
in the following table.
Inhibitor KI (M)
Inorganic phosphate:1 x10^-1M
Glucosamine-6-phosphate 7x10^-4M
NADPH 2.7 x10^-5M
(a) Which is the most effective inhibitor? Explain.
(b) Which inhibitor(s) is (are) likely to be completely ineffective
under normal cellular conditions? Explain.
C) NADPH H+ HO OH glucose-6-1 HO phosphate dehydrogenase H OH H OH Glucose-6-phosphate 6-Phosphoglucono-8-lactoneExplanation / Answer
Answer:
Based on the given information:
Yeast glucose-6-phosphate dehydrogenase Inhibitor Ki (M)
(a) Which is the most effective inhibitor? Explain.
(b) Which inhibitor(s) is (are) likely to be completely ineffective under normal cellular conditions? Explain.
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