Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) is an X chromosom

Question

Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) is an
X chromosome-linked recessive genetic condition. It predisposes
individuals with the allele (Xd) to hemolysis or destruction of red blood
cells and therefore low red blood cell counts (jaundice) as opposed to
the normal X allele (XG). Like sickle cell anemia, however, G6PD
deficient individuals have some resistance to malaria. Drawing upon the
information supplied here and your knowledge of sickle cell anemia,
answer the following questions.
a. Which genotype(s) should be most likely to manifest the
phenotype of low blood cell counts?

b.Which genotype(s) should have the highest fitness in regions
where malaria is present?

c.Which genotype(s) should have the highest fitness in regions
where malaria is absent?

d.In which human populations would you expect G6PD deficiency
alleles to be most prevalent? Name the geographic region(s).

Explanation / Answer

a.Xd Xd = low blood cell count: b.Xd XG higher fitness where malaria is present c. XG XG malaria absent

d. Mainly Africa, South america etc

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