Compare the repair of 3-methyladenine through base excision repair to repair of

Question

Compare the repair of 3-methyladenine through base excision repair to repair of O 6-methylguanine through direct reversal by a methyltransferase.

Categorize the appropriate items to their respective categories.

a) The same enzyme(s) can repair many molecules

b) The same enzyme(s) can be reused

c) The same enzyme(s) can repair only one molecule

d) more enzyme must be produced

e) Involved several different enzymes and different steps

f) repairs in one step

BASE EXCISION REPAIR or REPAIR BY A METHYLTRANSFERASE

Explanation / Answer

Answer:

Categorize the appropriate items to their respective categories.

a) The same enzyme(s) can repair many molecules - REPAIR BY A METHYLTRANSFERASE (three lesions repaired by MGMT are O6-methylguanine, O4-methylthymine, and methylphosphotriester)

b) The same enzyme(s) can be reused - BASE EXCISION REPAIR (DNA glycosylases can be reused unlike Methyltransferase repair where the enzyme becomes inactive and cannot be reused further)

c) The same enzyme(s) can repair only one molecule - BASE EXCISION REPAIR (mediated by DNA glycosylases, each of which can recognize a specific type of altered base in DNA)

d) more enzyme must be produced - REPAIR BY A METHYLTRANSFERASE

e) Involved several different enzymes and different steps - BASE EXCISION REPAIR (involves several different types of DNA glycosylases, several isoforms of DNA glycosylases are there and each type has a specific role)

f) repairs in one step -  REPAIR BY A METHYLTRANSFERASE (Methyltransferase based mechanism involves repairing DNA lesions in a single-step reaction)

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