CELL SIGNALING 1. What is the major difference between intracellular receptor me

Question

CELL SIGNALING 1. What is the major difference between intracellular receptor mediated cell signaling and membrane receptor mediated cell signaling? 2. What are the major characteristics of the G protein coupled signaling? 3. What are the major characteristics of protein tyrosine kinase receptor mediated cell signaling? What are the examples of ligands that bind to such kind of receptors? (IGF, VEGF, EGF PEDF..) 4. What types of biological tools can one develop to block a specific signaling pathway? ited States

Explanation / Answer

1. Differences

A. Intracellular receptors are found in cytoplasm. Cell surface receptors are attached to the cell membrane

B. Intracellular receptors bind to ligands which can cross the plasma membrane. Cell surface receptors bind to external ligand molecules that can not cross the plasma membrane

C. Intracellular receptors can directly influence gene expression. No need to pass the signal onto other receptors or messenger. Cell surface receptors need different messenger molecules. These are few major differences between intracellular receptor mediated signalling and cell surface mediated signalling

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