Read the article (link is below) and answer the questions that follow in a paper

Question

Read the article (link is below) and answer the questions that follow in a paper format. (Paper has to be 1-page, 11-inch font- single-spaced). COPY THE BELOW LINK AND PASTE IN YOUR BROWSER.

https://www.sciencedirect.com/science/article/pii/S1097276513001329

Primary Paper HW assignment guidelines

Your primary paper consists of three parts:

1. In your own words, state the essential take home message of the paper assigned.

-Here you should briefly mention what was known about this topic before this paper was published

-Then state what the aim/goal/purpose of this published study was. In other words, what did the authors set out to do?

-Also describe why this research is important (if you think it is important)/ what are the researchers hoping to contribute to the existing knowledge.

2. State how the authors demonstrated the essential point of the paper: what experiments and what methods they used to prove the point

-In this section you should link how a particular approach/method was used to obtain a particular result and why it would be important/relevant. For example:

-Authors used method A to get/show result B. Result B is important because (it supports their original hypothesis in the following way/describe how/ or it provides novel findings regarding mechanism X

-Continue the bulleted list to correlate specific method with specific result and how it supports the claims made in the paper.

3. Discuss the strengths and significance of the paper and also the weaknesses and indicate additional lines of investigation that you think would be worth pursuing that were opened up by the paper.

-Here I want you to critique the experimental approach and author’s conclusions, not their writing style or format of the paper. Also, keep in mind that these are primary research articles published in scientific journals, so they are intended for a scientific, not general audience. Hence the language could be a bit dense.

-I want you to be very specific here. Do not write general and vague statements. Instead, refer to specific data in the paper (in figure X, or table Y) and indicate any possible flaws or limitations of the experiment.

-Propose possible future directions or follow up studies. You can look up papers that cited this research or follow up on the last author’s subsequent research.

-Explain if this paper contributed anything new to the field and if it enabled better understanding of the subject

Explanation / Answer

1) Eukaryotic genome packaging within nucleus, compaction of DNA into nucleosome, information regarding DNA and histone modification pattern , transcription sites, transcription factor binding sites, descrete chromosome conformation, About chromatin and gene loop and their function, ATP dependent chromatin remodelling enzyme modulate the genome , 1 remodelar per 14 nucleosome present in human cell, how remodeling factor capable to recognize acetylated and methylated histone lysine residue. Mechanism by which targeting of chromatin remodeling enzyme to specific loci. All of this previously known about this topic.

Aim of the study

To establish linear map of genome information that shed light on the regulation of DNA dependent process.

They wanted to know how DNA dependent process regulation affected by structural arrangement of DNA.

Mechanism by which Isw2 targeted to specific loci across genome

This research is important because it help to understand how DNA structure affect DNA dependent regulation which help us to interlinked verious process to verious structure arrangement of DNA. This important to find out the treatment of diseases that occur due to poor remodeling and defect in normal structural organization.

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