Of the amino Acids aspartate (pKa 3.9), glutamate ( pKa 4.1)lysine (pKa 10.5) ar

Question

Of the amino Acids aspartate (pKa 3.9), glutamate ( pKa 4.1)lysine (pKa 10.5) arginine ( pKa 12.5) and histidine ( pKa 6.0) which will have charged side chains in the stomach ph (2.0)? Which will have charged chains in the bloodstream ph is 7.4. Please explained the how you come up with the answer. Of the amino Acids aspartate (pKa 3.9), glutamate ( pKa 4.1)lysine (pKa 10.5) arginine ( pKa 12.5) and histidine ( pKa 6.0) which will have charged side chains in the stomach ph (2.0)? Which will have charged chains in the bloodstream ph is 7.4. Please explained the how you come up with the answer. Which will have charged chains in the bloodstream ph is 7.4. Please explained the how you come up with the answer.

Explanation / Answer

At pH 2 non of the amino acids listed in the question will have a charged side chain. The pKa value of these amino acids neither equal nor less than 2. Deprotonation of the side chains occur when pH>pKa.

Aspartate (pKa3.9), Glutamate(pKa 4.1) and Histidine(pKa 6.0) will be charged in the bloodstream. As the pKa values of their respective side chains is less than the pH of the blood.

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