FIG. 18.9 ESSENTIALS Oxygen-Hemoglobin Binding Curves Binding Properties of Adul
ID: 200642 • Letter: F
Question
FIG. 18.9 ESSENTIALS Oxygen-Hemoglobin Binding Curves Binding Properties of Adult and Fetal Hemoglobin (a) The oxyhemoglobin saturation curve is determined in vitro in the laboratory. (b) Matemal and fetal hemoglobin have different oxygen- binding properties. 100- Maternal hemoglobin Hemoglobin saturation, % a 88333333 TTTTTTTTO Hemoglobin saturation, % 68: 88 20 40' 60 80 100 Resting cell Alveoli Po, (mm Hg) O 20 40 6080 100 120 Po (mm Hg) Physical Factors Alter Hemoglobin's Affinity for Oxygen (c) Effect of pH (d) Effect of temperature (e) Effect of Pco, 100- 20°C 57°C off- Pon Hemoglobin saturation, % 8 & 2 3 Hemoglobin saturation, % 8 8 8 Hemoglobin saturation, % 8 8 8 9 a //Pcos - 20 mm Hg /Poo - 40 mm Hg HAPcog 80 mm Hg 0 20 40 60 80 100 Po, (mm Hg) O 20 40 6080 100 0 20 40 60 80 100 Pop (mm Hg) (1) Effect of the metabolic compound 2,3-BPG Hemoglobin saturation, % 8 8 8 8 8 " No 2.3-BPG Normal 2.3-BPG Added 2,3-BPG GRAPH QUESTIONS 1. For the graph in (a): (a) When the Po, is 20 mm Hg, what is the percent O2 saturation of hemoglobin? (b) At what Po, is hemoglobin 50% saturated with O2? 2. At a Po, of 20 mm Hg, how much more oxygen is released at en exercising muscle cell whose pH is 7.2 than at a cell with a pH of 7.47 3. What happens to oxygen release when the exercising muscle cell warms up? 4. Blood stored in blood banks loses its normal content of 2,3-BPG. Is this good or bad? Explain. 5. Because of incomplete gas exchange across the thick membranes of the placenta, hemoglobin in fetal blood leaving the placenta is 50% saturated with oxygen. What is the Po, of that placerital blood? 6. Blood in the vena cava of the fetus has a Po, around 10 mm Hg. What is the percent O, saturation of maternal hemoglobin at the same Po? 0 20 40 6080 100 Pop (mm Hg)Explanation / Answer
ANSWER:
hemoglobin in blood at the alveoli (Po2 = 100 mm Hg) is saturated almost 98-99%.
hemoglobin at the resting tissues is saturated to almost 70% and the rest is slightly rising up.
when Pco2 of the tissues is increased from 40 mm Hg to 80 mm Hg hemoglobin saturation is decreasing and PO2 is increasing.
if tissue temperature is decreased from 37 C to 20 C, PO2 decreases.
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