Hemophilia is an x-linked recessive disease. Polydactyly is an autosomal dominan

Question

Hemophilia is an x-linked recessive disease. Polydactyly is an autosomal dominant trait. You are advising a couple that are about to have a child. The dad has hemophilia and polydactyly and the mom is phenotypically normal. The mom's father also has hemophilia. Dad is assumed to be heterozygous at the gene that controls polydactyly because it is a rare trait in the population. (10pts) 3. a. List the parent genotypes: Dad:_ Mom: b. What is the probability that the offspring will... i. be polydactyl: ii. have hemophilia: iii. be polydactyly and have hemophilia: iv. be completely normal:

Explanation / Answer

(3).

a. Dad - AAp + XhY Mom - AA + XhX

b.

i) probability of offspring being polydactyl is 1/2.

ii) probability of hemophilia in offspring is 1/2.

iii) probability of polydactyly and hemophilia is 1/4.

iv) probabilty of being completely normal is 1/4 (including "only" phenotypically normal)

A Ap A AA AAp A AA AAp

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