Hemophilia is an X-linked condition. A person with the disease hemophilia has bl

Question

Hemophilia is an X-linked condition. A person with the disease hemophilia has blood that does not clot normally. Normal blood clotting is dominant and Hemophilia is recessive. Ahmed is a male who has hemophilia. Ahmed is worried about what would happen if he marries a woman who has normal blood clotting also but who is a carrier of the Hemophilia allele.

A) What is Ahmed’s genotype? (use proper X-linked notation!)___________

B) What would be the genotype of a woman who is a carrier for hemophilia? (use proper X-linked notation!) ___________

C) Show a Punnet square for the possible offspring from the genotypes in parts A and B.

Explanation / Answer

A. Ahmed's genotype would be XHY

B. As the woman is a carrier, only one allele out of two would be affected. So the genotype would be XHX

C.

XHY x XHX

25% of daughters are hemophilic

25% of sons are hemophilic

25% of daughters are carriers

25% of sons are normal

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