Please answer EVERY QUESTION Problem Set Questions: 1) What is the difference be

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Please answer EVERY QUESTION
Problem Set Questions: 1) What is the difference between "structural", "sequence", and "functional" protein motifs? Can "functional" motifs also be "structural", and/or sequence" motifs? 2) The "EF hand" motif is a functional motif that binds Ca2*, but generally this arrangement of secondary structure elements is also a type of structural motif. Which structural motif is the EF hand? 3) Amino acid sequence is the primary structure of proteins, and as we have seen thus far in BCH 3125, amino acid sequence determines protein structure. If sequence motifs always have a similar sequence, shouldn't they have a similar structure? What then is the difference between a structural motif and a sequence motif? 4) "Domains are the fundamental building blocks in the evolution of complex protein structure. Gene duplication and genetic recombination have resulted in the combinatorial creation of multifunctional proteins by mixing and matching domains." (Kuriyan et al. Molecules of Life, page 133) Explain, in your own words, what this means, and provide an example.

Explanation / Answer

Ans 1: Structural motif refers to connecting link between secondary structures e.g Helix turn Helix motif.

Sequence motifs are conserved amino acid residues that are functionaly important and present at periodic distances.

Functional motif: The term is not used but the structural and sequence motifs can serve as functional motifs as well.

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