14. Consider this human pedigree for a vision defect (ndividuals with a sash wer

Question

14. Consider this human pedigree for a vision defect (ndividuals with a sash were not phenotyped); Z10 5 67 8 9 10 11 12 13 14 Which explanations for the genetic basis of the trait are consistent with the pedigree? a) mitochondrial inheritance b) autosomal dominant inheritance c) sex-linked dominant inheritance d) a or c. e) b or c 15. For the pedigree in Q14, which of the following best represents the genotype oflI-5? Let D represent a dominant allele, d represent a recessive allele for the trait, MD represent matemal inheritance.) a) MD b) D/d d) MD or XpX e) D/d or Xx 16. To study mammalian segmentation in the mouse, zygotically-acting mutations are generated. A recessive mutation is identified. It causes all seven cervical (neck) vertebrae to be missing, Given the striking evolutionary conservation of many aspects of development in mice and Drosophila, one way to figure out which gene is mutated is to look for a gene affecting an analogous process in Drosophila. What type of segmentation gene in Drosophila is most analogous to the loss of seven cervical vertebra produced by the recessive mouse mutation. a) coordinate gene b) gap gene c) pair-rule gene d) segment polarity gene e) homeotic gene

Explanation / Answer

14) a or c as the parents phenotype is not known.

15) MD or XD/Xd because it can be due to maternal or sex dominant inheritance

16) segment polarity gene

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