8. Which of the following molecules is likely to inactivate serine proteases by

Question

8. Which of the following molecules is likely to inactivate serine proteases by binding covalently to the catalytic serine residue at the active site; this enzyme-inhibitor bond is not cleaved by the enzyme A) Phenyl-methane-sulfonyl-fluoride (PMSF) B) Methane-sulfonyl-fluoride C) Methane D) SO2 E) F Series "Exclosure Plots" Point "Middle Value: 17.84 9. Which of the following pentapeptides would yield two tripeptides after incubation with chymotrypsin? A) SER - GLY - PHE PHE - GLU -TYR B) SER - GLY - PHE - ASP- GLU - TYR C) SER - GLY - PHE - ASP- PHE- GLU D) SER - GLY - ASP PHE GLU-LYS E) PHE - GLY - SER - PHE - GLU - LYS

Explanation / Answer

1) Phenyl-methane-sulfonyl-fluoride (PMSF) - Phenyl-methane-sulfonyl-fluoride (PMSF) irreversibly inactivates serine proteases by binding covalently to the catalytic serine residue at the active site. PMSF does not inhibit all serine proteases and does not bind to serine residues of other proteins.

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