Ferguson-Smith et al. (1976) measured the production of the red blood cell enzym

Question

Ferguson-Smith et al. (1976) measured the production of the red blood cell enzyme adenylate kinase (AK) in 7 patients heterozygous for deletions or duplications of specific segments of chromosome 9 (shown below; p and q indicate short and long arms, respectively; numbers indicate location within an arm and “ter” indicates the very endmost portion of the chromosome arm). They obtained the following results:

In which region of chromosome 9 does the AK locus appear to be located? Explain how you arrived at that conclusion.

Explanation / Answer

As we can see that there is no change in the activity of AK enzyme when region upon duplication region pter to q12

That means that the AK enzyme is located on the q arm of the chromosome that too after q12 region.

When there is the duplication of q12-q33 and q31-qter there is increased activity on AK only upon the duplication of q31-qter.

So the difference between the region q12-q33 and q31-qter is qter region.

So AK locus is present ar the qter Region of the 9th chromosome

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