1. What is the resting membrane potential for the conditions given above? Please

Question

1. What is the resting membrane potential for the conditions given above?

Please give detailed explanation

HW5 - Read-Only - Compatibility Mode Surbhi Mehta - × File Insert Draw Design Layout References Mailings Review View Help Tell me what you want to do Share- Find - AaBbCcl AaBbC -ab Replace Paste 1 Normal No Spac... Heading abe X2 Select Font Paragraph Editing Problem set 5: Synapses (12 points) Potentially useful information: Nernst Equation (for cations): E(mV) = 61 log(Co/Ci) Goldman Equation: Em V)-6l logNPr(KJ+Pe[Cn The following conditions apply to the next three questions Intracellular mlA) 12 118 10 Ion Extracellular (mlM) 142 4.0 110 Permeability (rest) Permeability (Peak, AP) 25 Na* Kt Ch 0.04 4.0 0.5 0.5 1. What is the resting membrane potential for the conditions given above? Page 1 of 2 237 words 100% 4:48 PM 0 Type here to search "da 2/28/2018

Explanation / Answer

1. Resting membrane potential for the condition given above?

E(mV) = 61 log [ (PNa[Na]out + Pk[K]out + Pcl[Cl]out) / (PNa[Na]in+ Pk[K]in + Pcl[Cl]in)

= 61 log ( [142+40+110] / [12+118+10] )

= 61 log ( 292 / 140 )

= 61 log 2.1

= 61 x 0.322

= 19.65 mV

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