Bio335 Chapter 4 Homework Worksheet-Ig Gene Rearrangement-Saved to my Mac Q- Sea

Question

Bio335 Chapter 4 Homework Worksheet-Ig Gene Rearrangement-Saved to my Mac Q- Searc out References Mailings Review View No Spacing 11. Isotype (class) swit effector properties, and is determined by the type of same, and the V regions of both heavy and light chains remain the same (not counting somatic bypermutation). ching is a way to produce antibodies with the same antigen specificity, but with different chain-_ region. The light chains remain the 12. Class switching is facilitated by action of the enzyme which introduces hypermutation and double- stranded breaks atregions (S) located 5" to C regions. Regular DNA repair enzymes for joining non- homologous DNA ends repair the S regions, which results in looping out and excision of intervening sequences to join VDJ region with new C region. Describe how a B cell that was producing IgM now switches to producing IgG1

Explanation / Answer

In isotype switching of antibody constant region of the heavy chain is changed but the variable region of the heavy chain remains the same.

Class switching is facilitated by the action of 'activation-induced cytidine deaminase(AID)' enzyme which breaks the double staranded at switch region.

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