Chloride ion (Cl-) concentrations are approximately 10x higher outside of cells

Question

Chloride ion (Cl-) concentrations are approximately 10x higher outside of cells than inside. Imagine you discovered a novel protein that is required in liver cells for transporting Cl- out of the cell up its concentration gradient, and further found that this protein only functions if the Na+/K+ ATPase is active. Which of the following might you reasonably conclude about the Cl- transport protein? A. It could be a Na+/Cl- symporter B. It could be a K+/Cl- symporter C. It could be a Cl- ATPase D. It must be a Cl- channel Chloride ion (Cl-) concentrations are approximately 10x higher outside of cells than inside. Imagine you discovered a novel protein that is required in liver cells for transporting Cl- out of the cell up its concentration gradient, and further found that this protein only functions if the Na+/K+ ATPase is active. Which of the following might you reasonably conclude about the Cl- transport protein? A. It could be a Na+/Cl- symporter B. It could be a K+/Cl- symporter C. It could be a Cl- ATPase D. It must be a Cl- channel A. It could be a Na+/Cl- symporter B. It could be a K+/Cl- symporter C. It could be a Cl- ATPase D. It must be a Cl- channel

Explanation / Answer

B. It could be a K+/Cl- symporter.

The Na+/K+ gradient provides it energy. Along the down path of Na+ gradient for co-transport into the cell, symport with Na+ is required. However Cl- is transported out of the cell by our novel protein.

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